Illustrative only

GeographyUS

Patient funnel

Patient funnel for Heart Failure in the US: 262 million adults narrow to 900,000 currently treated patients at the published segment and the base-case assumptions.

Where patients are lost

19%never diagnosed

79%of diagnosed outside the segment

22%of eligible untreated

430,000addressable for an add-on · 48% of treated ·Asset Deep Dive

Assumptions

81% of prevalent

Base case

21% of diagnosed

Base case

78% of eligible

Base case